Year: 2024
Type: article
Abstract: Three critical advances in simplifying the adoption of P(V)-based stereopure, phosphorothioate-containing oligonucleotide synthesis are reported. A more inexpensive phosphorus–sulfur incorporation reagent ( Ψ Br ) is introduced, a robust linker system was developed, and a systematic study of common nucleobase protecting groups was performed to significantly reduce the barrier to adoption of this technology.
Source: Organic Letters
Institution: University of Pisa
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G1442429282, G219646730, G5105683813
OpenAlex ID: W4405593555