Work

Bacterial intragenic inversions: a new layer of diversity

Year: 2024

Type: article

Abstract: DNA inversions in bacteria were known to create diversity through intergenic or partial intergenic changes. Now, Chanin, West, et al. reveal intragenic inversions, enabling single genes to encode multiple protein variants via sequence recoding or truncation - an unexpected mechanism for expanding protein diversity without increasing genome size.

Source: Trends in Genetics

DOI: 10.1016/j.tig.2024.12.002

Authors: Brantley Hall, Xiaofang Jiang

Institutions: University of Maryland, College Park, National Institutes of Health, United States National Library of Medicine

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $7,030

Funders: Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institute of General Medical Sciences