Work

Non-invasive pressure-volume loop derived LV efficiency, contractility, and stroke work in patients with Duchenne muscular dystrophy

Year: 2024

Type: article

Abstract: Background Early detection of left ventricular (LV) dysfunction before the onset of Duchenne muscular dystrophy–associated cardiomyopathy (DMDAC) may direct earlier clinical management. Ejection fraction (EF) is the most measured parameter. However, a decline in EF is a late finding in the assessment of heart failure. Objective This study aims to measure non-invasive pressure-volume loop-derived ventricular efficiency, contractility , and stroke work (SW) in DMDAC patients and investigate how these measured parameters correlate with EF in patients who develop DMDAC. Methods The current study performed a retrospective case-control study of thirty DMDAC patients who underwent two serial CMR imaging from 2016 to 2023. The patients were divided into +DMDAC and –DMDAC based on EF. Brachial pressures from cuff sphygmomanometer and CMR short axis steady-state free-precession images covering the LV were acquired, and non-invasive pressure-volume loop derived efficiency, contractility , and SW were obtained using an elastance based model. Results Efficiency and contractility correlated significantly (r = 0.99, p < 0.01) and (r = 0.74, p < 0.01), respectively, with EF for all subjects. Conversely, no significant correlation was found between SW and EF. Furthermore, efficiency and contractility were significantly less in the EF < 55 % group than when compared to EF ≥ 55 % (p < 0.001), but there was no significant difference in SW for both categories. Conclusion Efficiency and contractility show a significant correlation with EF, with future work needed to determine if they hold prognostic information toward developing DMDAC.

Source: Progress in Pediatric Cardiology

DOI: 10.1016/j.ppedcard.2024.101802

Authors: Israel O. Ajiboye, Michael D. Taylor, Rupak K. Banerjee

Institutions: University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati VA Medical Center

Language: English

Topic: Cardiovascular Function and Risk Factors

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,610