Work

Glutaraldehyde functionalized reduced graphene oxide based resistive sensors for detection of PCA3

Year: 2024

Type: article

Abstract: PCA3 RNA. Notably, the device exhibited stability over a period of two weeks and displayed high selectivity for PCA3. The developed RGO-GA/ss-DNA/PCA3 sensor was tested with RNA extracted from multiple prostate cancer cell lines and other cancer cell lines and demonstrated response only to RNA extracted from LNCaP as it was the only cell line expression of PCA3. The findings from the developed sensor were cross-validated with the observations of a semi quantitative polymerase chain reaction (qPCR), and were found to be closely matched.

Source: Journal of Materials Chemistry B

DOI: 10.1039/d4tb02512a

Authors: Bolivia Konthoujam, Nikita Bhandari, Shridhar C. Ghagane, Rajendra B. Nerli, Sudhanshu Shukla, Ruma Ghosh

Institutions: Indian Institute of Technology Dharwad, KLE Academy of Higher Education and Research, KLE Society Hospital

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Science and Engineering Research Board