Role of repeat staging laparoscopy in locoregionally advanced gastric or gastroesophageal cancer after neoadjuvant therapy
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background: Nowadays there are no international recommendations regarding the necessity of repeated diagnostic laparoscopy (with cytological examination or without it) after preoperative chemotherapy for resectable gastric cancer Purpose: To determine the indications for the repeated laparoscopic surgery in gastric or gastroesophageal cancer patients Materials and methods: The information on 449 IB-III stage gastric cancer patients was analyzed. After 4 cycles of chemotherapy 52 patients underwent diagnostic laparoscopy with peritoneal fluid cytology testing. Results: The multifactorial analysis showed that tumor progression detected on CT scans and gastroscopy, subtotal gastric involvement (p < 0,014), and diffuse Lauren type (p < 0,026) were statistically significant negative prognostic factors after preoperative chemotherapy. The 8 weeks interval after neoadjuvant chemotherapy wasn’t significant. Results: The repeat staging laparoscopy after neoadjuvant chemotherapy is safe and may be considered for a certain category of patients.
Source: Malignant tumours
Authors: I. G. Avdyukhin, A. E. Kalinin, O. A. Egenov, M. G. Abgaryan, T. A. Titova, I. S. Stilidi
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4405600219