Work

Antiviral Activity of the Solutions of Dinitrosyl Iron Complex Delivered to SARS-CoV-2-Infected Syrian Hamsters Placed in a Nose-Only Inhalation Exposure Chamber

Year: 2024

Type: article

Abstract: No differences were found in antiviral action of the solutions of binuclear dinitrosyl iron complexes with glutathione (B-DNIC-GSH) and sodium diethyldithiocarbamate (DETC) delivered sequentially to SARSCoV-2-infected Syrian hamsters in nose-only (the present study) inhalation or whole-body exposure chambers. In a whole-body exposure chamber, the animal became wet and it led only to a decrease in the level of mononuclear DNIC (M-DNIC) with thiol-containing proteins in lungs resulting in diminished EPR signal while the total Band M-DNIC pool remained unchanged. It is suggested that antiviral activity of D-DNICGSH + DETC against SARS-CoV-2 virus is due to nitrosonium cations released from B-DNIC-GSH in its decomposition induced by DETC. Without additional aerosol inhalation delivery of the solutions of DETC to animals, complex with mercaptosuccinate that is less stable than B-DNIC-GSH exerted similar antiviral effect on Syrian hamster model.

Source: Биофизика

DOI: 10.31857/s0006302924060176

Authors: A. V Shipovalov, A. F Vanin, N. A Tkachev, O. V Pyankov, N. B Asanbaeva, S. V An’kov, E. G Bagryanskaya, A. M Baklanov, S. V Valiulin, M. E Stekleneva

Institutions: State Research Center of Virology and Biotechnology VECTOR, Semenov Institute of Chemical Physics, Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Institute of Chemical Kinetics and Combustion

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4405603088

FWCI: 0.635

Cites: 11

Cited by: 2

Related to: 10