Work

The Action of Dinitrosyl Iron Complexes with a Ligand Based on N-acethyl-L-cysteine upon Inhalation Delivery of These Complexes to Rats

Year: 2024

Type: article

Abstract: The objective of the present research was to study the action of dinitrosyl iron complexes (DNIC) with a ligand based on N-acetyl-L-cysteine upon long-term inhalation exposure of rats to this substance. It has been shown that as a result, NO stabilized forms pass efficiently through the alveolal membrane into the lung tissue leading to the accumulation of dinitrosyl iron complexes with protein ligands and to an increase in the total NO level in the lungs and other organs thereby inducing a significant and long-lasting hypotensive effect.

Source: Биофизика

DOI: 10.31857/s0006302924060181

Authors: A. A Timoshin, K. B Shumaev, V. L Lakomkin, A. A Abramov, E. K Ruuge

Institutions: National Medical Research Center of Cardiology, Russian Academy of Sciences, A N Bach Institute of Biochemistry, Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, Lomonosov Moscow State University

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4405603724

FWCI:

Cites: 20

Cited by:

Related to: 10