Work

Platelet Glycoprotein Ⅵ: A Novel Target for Antithrombotic Therapy in Cardiovascular Disease

Year: 2024

Type: article

Abstract: Platelets play an important role in thrombosis caused by acute coronary syndrome and stroke. As the main platelet collagen receptor, platelet glycoprotein Ⅵ (GPⅥ) is an important modulator in the activation and aggregation of platelets at vascular injury sites. Recently, GPⅥ has been identified as a potent antithrombotic target. The structure, properties, functions, and downstream signaling of GPⅥ are reviewed; its relationship with bleeding, thrombosis, and other diseases are discussed; and potential of GPⅥ as a future antiplatelet therapeutic target is summarized in this article.

Source: Cardiology Discovery

DOI: 10.1097/cd9.0000000000000137

Authors: Menglu Liu, Xueyan Zhao

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405610019

FWCI: 0.534

Cites: 106

Cited by: 2

Related to: 10