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Assessment of Osteoprotegerin and Receptor Activator of Nf-Kb Ligand in Malaysian Male Patients with Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study

Year: 2024

Type: article

Abstract: Background: Limited information exists regarding the pathophysiological interactions between osteoporosis and chronic obstructive pulmonary disease (COPD).Objective: To study the association of Osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-Β ligand (RANKL) in male COPD patients.Methods: An observational clinical study was conducted at Penang General Hospital in Malaysia.Participants were divided into three groups: COPD patients with osteoporosis, COPD patients without osteoporosis, and healthy participants of the same age groups.Serum OPG (sOPG) and RANKL (sRANKL) levels were investigated.Results: The mean age of COPD patients was 64.10 ± 10.04 years.COPD patients had lower body mass index (23.22± 6.43) than healthy participants (27.32 ± 6.80).The T-score was significantly lower among COPD patients than healthy participants (p = 0.018).The sOPG concentration among healthy participants was significantly higher (361.90 ± 29.10 pg/mL, p < 0.001) than in the other groups, while the sRANKL concentration was not significantly different.The serum OPG/RANKL concentration was markedly higher in the control group than in the COPD patient group (p < 0.05).The COPD patients with osteoporosis had significantly lower pulmonary parameters (forced expiratory volume in the first [FEV]1% and FEV 1 /[forced vital capacity] (FVC), p < 0.01) and more dyspnea (modified medical research council = 2.60 ± 0.78 versus 1.90 ± 0.70, p < 0.01) than did the patients without osteoporosis.Furthermore, patients with severe COPD had a 3 times greater risk of developing osteoporosis (OR = 2.997 [95% CI = 2.181, 4.118], p < 0.001), while spirometric parameters had a significant inverse relationship with osteoporosis (FEV 1 % OR = 0.970, [95% CI = 0.954, 0.986], p = 0.001; FEV 1 /FVC OR = 0.984, (95% CI = 0.970, 0.999], p = 0.035).Conclusion: The study concluded that COPD patients had lower sOPG levels, leading to decreased OPG/RANKL ratio and faster bone resorption.Low bone mineral density was associated with more severe COPD.(REV INVEST CLIN.2024;76(6):262-73)

Source: Revista de investigaci�n Cl�nica

DOI: 10.24875/ric.24000192