Work

An improved ultrasound-assisted synthesis of phenytoin suitable for undergraduate education

Year: 2024

Type: article

Abstract: A convenient and efficient method for undergraduate student experiments involves the one-pot synthesis of phenytoin from benzoin. This method utilized ultrasonic irradiation in the presence of basic catalyst at room temperature and atmospheric pressure, resulting in shortened reaction times, good yields, and excellent reproducibility. By employing a low-cost ultrasonic cleaner for ultrasonic irradiation in student experiments, the need for expensive equipment investment during the teaching process can be minimized. Consequently, this approach is suitable for widespread promotion and application in undergraduate education.

Source: Ultrasonics Sonochemistry

DOI: 10.1016/j.ultsonch.2024.107207

Authors: Baowei Yang, Xiandong Zhai, Runzhe Mei, Pu Wang, Yicheng Mei

Institutions: Jiangsu Food and Pharmaceutical Science College, Hong Kong University of Science and Technology, Northeast Forestry University

Language: English

Topic: Various Chemistry Research Topics

Subfield: Physical and Theoretical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,700

Funder: Jiangsu University