Exploring biomarkers of regular wine consumption in human urine: Targeted and untargeted metabolomics approaches
Year: 2024
Type: article
Study design: Observational Study
Abstract: The epidemiological assessment of wine consumption usually has been obtained using self-reporting questionnaires. In this study, two metabolomic approaches, targeted and untargeted, were applied to 24-h urine samples from a cohort of La Rioja (Spain) (aged 52–78), comparing moderate and daily wine consumers (20 males and 13 females) without diet intervention, versus non-consumers (8 males and 35 females). Results showed that the non-targeted metabolomics approach has allowed for the annotation of sixteen compounds in 24-h urine samples from regular wine-consumers that were not detected in the urine of non-wine consumers. Additionally, the targeted metabolomics approach showed a wide range of phenol metabolites, mainly hepatic phase-II conjugates, whose concentration was significantly higher in the urine of wine consumers. As a novelty, this study focuses on discovering the main urinary biomarkers of regular wine consumption involving free-living volunteers, without dietary intervention or restrictions that might alter their regular behaviors and lifestyles. • Metabolomics approaches determined wine-consumption biomarkers in urine samples. • LC-HRMS demonstrated potential with 16 compounds annotated in urine samples. • More metabolites were detected using HILIC than RP chromatography methods. • Wine biomarkers were consistent among regular wine consumers' urine samples. • Study results may apply to the general population regarding wine intake effects.
Source: Food Chemistry
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,620
Awards: G1175115578, G121809054, G1855990336, G210041235, G2200446304, G2262748287, G2309174360, G2464210460, G2601397997, G2660406951, G279363373, G300979063, G34346518, G3480869486, G3518538256, G3681454997, G3690828678, G4042783231, G425668148, G430777504, G4442677895, G4526231891, G4690028558, G5080475149, G5195188938, G5421974903, G7084143925, G8684520763, G897484643, G99296377
OpenAlex ID: W4405613323