Work

Immune Reconstitution Inflammatory Syndrome-Induced Thrombocytopenia in a Patient With HIV and Coccidioidomycosis

Year: 2024

Type: article

Abstract: Highly active antiretroviral therapy (HAART) is imperative in managing human immunodeficiency virus (HIV) infections. HAART aims to inhibit viral replication and improve immunity. Antiretroviral therapy has led to significant improvement in CD4-T cell counts and reductions in viral load, leading to improved overall immune function, increased survival, and decreased frequency of opportunistic infections. Immune reconstitution inflammatory syndrome (IRIS) is defined by a hyperinflammatory immune response within six months of initial treatment with HAART. It is caused by dysregulated inflammatory immune responses against pathogens. Herein, we discuss a rare presentation of IRIS-induced thrombocytopenia in a 20-year-old Hispanic male patient.

Source: Cureus

DOI: 10.7759/cureus.75978

Authors: Anthea Cheng, Simon Lalehzarian, Hridya Harimohan, Melanie Khamlong, Stanley Kim, Leila Moosavi

Institution: Kern Medical Center

Language: English

Topic: Infectious Diseases and Tuberculosis

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405614344