Year: 2024
Type: review
Study design: Systematic Review
Abstract: The intestinal microbiota plays a critical role in host immunity and might contribute to the significant variation between individuals' vaccine responses. A systematic search was done using MEDLINE and Embase to identify original human studies investigating the association between intestinal microbiota composition and humoral and cellular vaccine responses. In total, 30 publications (26 studies, 14 in infants, 12 in adults), were included. Of these, 26 publications found an association between intestinal microbiota composition and vaccine responses. A beneficial effect of Actynomycetota (particularly Bifidobacterium) and a detrimental effect of Pseudomonadota (particularly Gammaproteobacteria) were observed across studies. Study designs were highly heterogenous, with variation in vaccine type, outcome measure, timing of stool analysis and analysis methods. Overall, studies support the concept that the composition of the intestinal microbiota influences vaccine responses. Further adequately powered studies are needed to confirm this association and inform potential microbiota-targeted interventions to optimise vaccine responses.
Source: npj Vaccines
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,196
Awards: Nasopharyngeal and gastrointestinal microbiota dynamics in Cambodian children following healthcare exposure, Antibiotic-induced disruption of the maternal and infant microbiota and adverse health outcomes – The ABERRANT study, NapBiome: Targeting gut microbiota and sleep rhythm to improve developmental and behavioral outcomes in early childhood
OpenAlex ID: W4405616544