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Intestinal barrier function declines during polycystic kidney disease progression

Year: 2024

Type: article

Abstract: Though autosomal dominant polycystic kidney disease (ADPKD) is a multisystem disorder, this is the first study to explore a kidney-gut contribution to disease progression. We identified a tightened intestinal epithelial barrier in early PKD, which becomes leaky as kidneys become more cystic, accompanied by a sustained loss of fecal water. Given the only approved ADPKD therapeutic yields adverse aquaretic events, this study emphasizes the need to evaluate extrarenal water loss in patients before prescribing.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00058.2024

Authors: Randee Sedaka, Caleb Lovelady, Emily Hallit, Branden Duyvestyn, Sejal Shinde, Aida Moran-Reyna, Goo Lee, Shinobu Yamaguchi, Craig L. Maynard, Takamitsu Saigusa

Institutions: University of Alabama at Birmingham, UAB Medicine

Language: English

Topic: Genetic and Kidney Cyst Diseases

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, University of California, San Diego, National Institute of Diabetes and Digestive and Kidney Diseases, Division of Diabetes, Endocrinology, and Metabolic Diseases

Awards: G4252043515, G4644639351, G5950577451, G7209653886, G8964865264, UAB Childhood Cystic Kidney Disease Center (UAB-CCKDC), The Role of Wheat-Gluten in Polycystic Kidney Disease

OpenAlex ID: W4405617635

FWCI:

Cites: 48

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Related to: 10