Serum Interleukin-1β and Interleukin-6 levels in children with status epilepticus in Indonesia
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background and objectives. The most common neurological emergency is status epilepticus (SE). The morbidity and mortality of SE are still high. Immune system activation and inflammation play a role in neuronal death in humans with SE. Interleukin 1β (IL-1β) and interleukin 6 (IL-6) are important pro-inflammatory cytokines in seizure susceptibility and brain cell death. This study aims to compare serum IL-1β and IL-6 levels of between children with SE and non-SE seizures. Material and methods. This study employed an analytic observational method at Dr. Soetomo General Academic Hospital Surabaya. The subjects were divided seizures into SE and non-SE seizures. The patients underwent a blood test after the initial assessment in the form of anamnesis, physical examination. Serum IL-1β and IL-6 levels were measured by using enzyme-linked immunosorbent assay (ELISA). Differences between the SE and non-SE groups were determined by using Fisher’s exact test or the Mann-Whitney test. Results. Forty patients participated in the study. In the SE seizure group, the median was 16 months, and the male gender was more prevalent (75%). The clinical manifestations that appeared more frequently in the SE group were fever and decreased consciousness. Most patients were alive at the end of the study: four patients in the SE group died. There was no significant difference in serum IL-1β between the groups (P=0.372). However, serum IL-6 serum levels were significantly higher in the SE group compared with the non-SE group (P=0.001). Conclusions. Serum IL-1β levels did not differ between the SE and non-SE groups, but serum IL-6 levels were higher in the SE group.
Source: Romanian Journal of Pediatrics
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $216
OpenAlex ID: W4405618360