Selective Synthesis of Amino Acid Conjugates of Glycyrrhizic Acid Using N-Oxyphthalimide and N,N′-Dicyclohexylcarbodiimide
Year: 2024
Type: article
Abstract: A selective synthesis of amino acid conjugates of glycyrrhizic acid containing amino acid residues in the carbohydrate part of the glycoside was proposed using N-oxyphthalimide (HOPt) and N,N′-dicyclohexylcarbodiimide (DCC), tert-butyl and benzyl/4-nitrobenzyl esters of L-amino acids with yields of 55–60%. Free conjugates of glycyrrhizic acid with valine, isoleucine, methionine, phenylalanine, leucine, tyrosine and glutamic acid were obtained by deblocking the ester groups.
Source: Журнал Общей Химии
Authors: A. I. Fairushina, S. F. Petrova, L. A. Baltina
Institution: Ufa Institute of Chemistry
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4405622132