Work

Reactions of Pyrimidine-2-sulfenyl Chloride with Alkylvinyl and Allyl Ethers

Year: 2024

Type: article

Abstract: The regioselective synthesis of novel thiazolo[3,2-a]pyrimidine derivatives in 52–92% yields was developed based on the reaction of pyrimidine-2-sulfenyl chloride with unsaturated ethers. The reaction with allylic and vinylic ethers proceed regioselectively, but with the opposite regiochemistry. The reaction with allylic ethers lead to 2-substituted thiazolo[3,2-a]pyrimidine derivatives whereas 3-organyloxy derivatives are formed in the reaction with vinylic ethers.

Source: Журнал Общей Химии

DOI: 10.31857/s0044460x24070058

Authors: R. S. Ishigeev, S. V. Amosova, V. A. Potapov

Institutions: A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences

Language: English

Topic: Synthesis of heterocyclic compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4405622157

FWCI:

Cites: 27

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Related to: 10