Work

The organum vasculosum of the lamina terminalis contributes to neurohumoral mechanisms of renal vascular hypertension

Year: 2024

Type: article

Abstract: Renovascular hypertension (RVHT), accounting for 1%-5% of high blood pressure cases, is the most common secondary hypertension resistant to treatment. In two-kidney one-clip (2K1C) hypertensive rats, renal artery stenosis triggers sympathetic nervous system activation, increased vasopressin, water intake, and inflammation. OVLT lesions prevented these responses, similar to afferent renal denervation. This study suggests that OVLT plays a key role in 2K1C hypertension pathogenesis and interacts with afferent renal nerves. Future studies will explore the underlying mechanisms.

Source: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI: 10.1152/ajpregu.00203.2024

Authors: Mariana R. Lauar, Nayara Pestana-Oliveira, John P. Collister, Lucy Vulchanova, Louise C. Evans, John W. Osborn

Institution: University of Minnesota

Language: English

Topic: Renin-Angiotensin System Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: University of Minnesota, National Heart, Lung, and Blood Institute