Work

Why study the T1D remission phase in the pediatric population?

Year: 2024

Type: article

Abstract: Childhood-onset type 1 diabetes (T1D) is a severe disease, not only in terms of disabling late complications leading to shortened life expectancy but also in terms of the heavy burden on the patients and their families due to an extremely demanding therapy. The etiology of T1D is, in spite of intensive biochemical, immunological, epidemiological, and clinical research during the last 100 years, still unknown. T1D seems to be a result of a complex interplay between genetic predisposition, the immune system, and environmental factors1,2 causing attrition and death of the insulin-producing pancreatic β cells, resulting in a life-long requirement for exogenous insulin. The progressive loss of β cells is mainly caused by autoimmune inflammation.

Source: Jornal de Pediatria

DOI: 10.1016/j.jped.2024.12.001

Author: Jesper Johannesen

Institutions: University of Copenhagen, Copenhagen University Hospital, Steno Diabetes Center Copenhagen

Language: English

Topic: Diabetes and associated disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,800