Assessing a hyperpolarized [1-13C]-labeled alanine derivative enhanced via parahydrogen for in vivo studies
Year: 2024
Type: article
Abstract: Magnetic Resonance Imaging (MRI) is a valuable non-invasive technique widely used in clinical diagnostics; however, its sensitivity is limited, posing challenges in various medical conditions. Hyperpolarization techniques represent a promising approach to dramatically enhance signals in magnetic resonance imaging (MRI) and allow the use endogenous metabolites as contrast media. In this study, we synthesized N-acetyl-alanine ethyl ester as a novel imaging agent and assessed its in vivo imaging capabilities, potentially offering diagnostic and monitoring capabilities for cardiovascular diseases. It is derived from N-acetyl-alanine, an endogenous metabolic end product of protein degradation. The in vivo experiments resulted in high-resolution images of the circulatory system acquired within sub-seconds. Our findings not only highlight the potential preclinical utility of this new, generally available agent, but also advance the frontier of hyperpolarized contrast agents.
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,500
Awards: Relaxationszeiten von KernspinSingulettZuständen als ein neuer Kontrast für die Magnetresonanz, Hyperpolarisierte 15N –Sonden zur Detektion von Kupfer und Zinkionen, G8103733613, KernSingulettZustände in selbstorganisierenden Nanostrukturen als Kontrastmittel für die Magnetresonanzbildgebung, G8953575842
OpenAlex ID: W4405634323