Work

Effects of tryptophan supplementation on performance, intestinal morphology and protein abundance of tight junction protein and indoleamine 2, 3-dioxygenase in weaned pigs

Year: 2024

Type: article

Abstract: This study determined the effect ofÂ tryptophan (Trp) supplementation onÂ the protein abundance ofÂ intestinal tight junction and indoleamine 2, 3-dioxygenase (IDO) inÂ weaned pigs. Ninety-six White Ă Landrace Ă Duroc piglets (5.31Â ±Â 0.54Â kg) were selected inÂ aÂ growth trial and the experiment lasted for 30Â days. The basal diet based onÂ corn and soybean contained Trp atÂ 2.4Â g/kg. The dietary treatments consisted ofÂ aÂ basal diet orÂ aÂ basal diet + 500Â mg/kg Trp. OnÂ the 31st day, 12 pigs (1 pig per pen) were randomly selected and slaughtered inÂ order toÂ collect samples for subsequent analysis. Dietary supplementation with Trp improved the villus height and protein abundance ofÂ Zonula occludens protein 1 (ZO-1) inÂ the duodenum and the jejunum (PÂ < 0.05), increased the protein abundance ofÂ Claudin-1 inÂ the duodenum (PÂ < 0.05) and IDO expression inÂ the ileum (PÂ <Â 0.05), and reduced the urea nitrogen concentrationÂ inÂ the serum and the ZO-1 protein abundance ofÂ the ileum inÂ weaned pigs (P <Â 0.05).

Source: Czech Journal of Animal Science

DOI: 10.17221/65/2024-cjas

Authors: Pei Mao, Naizhi Hu, Mengmeng Gao, Lingping Zhao, Chengsheng Song, Wenfeng Ma

Institution: Henan University of Science and Technology

Language: English

Topic: Animal Nutrition and Physiology

Subfield: Animal Science and Zoology

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDGs: Zero hunger, Good health and well-being

Open Access status: gold

Estimated APC paid: $609