Year: 2024
Type: article
Abstract: An acid-promoted dearomative rearrangement of O -arylhydroxylamines affords 2-aminocyclohexadien-1-ones, which can in turn be reductively quenched for the synthesis of trans -aminoalcohols on a cyclohexadiene core. This method serves as an efficient entry to the pharmaceutically relevant 1-arylcyclohexylamine scaffold in two steps (one purification) from commercially available or readily prepared 2-arylphenols.
Source: The Journal of Organic Chemistry
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Awards: G2392772430, MRI: Upgrade of a 600 MHz Spectrometer for high-sensitivity Nuclear Magnetic Resonance (NMR), MRI: Acquisition of a Mass Spectrometer, G3707295272, MRI: Acquisition of a Modern Single Crystal X-ray Diffractometer for Research and Education, G4513771819, G4972501803, G5998872585, G6273545833, G8083375506, G8804900633, Synthesis of Bioactive Small Molecule Building Blocks
OpenAlex ID: W4405643287