Year: 2024
Type: article
Study design: Observational Study
Abstract: Aim – to evaluate the association among appendicular lean mass and immunological markers of blood serum in women with rheumatoid arthritis (RA).Material and methods. 200 women with RA (median age – 60.0 [52.5; 65.5] years) were enrolled in the study. Using dual-energy X-ray absorptiometry appendicular lean mass (ALM) was measured to determine the sarcopenic phenotype of body composition. The assessment of C-reactive protein (CRP), rheumatoid factor, and antibodies to cyclic citrullinated peptide was also performed. The levels of serum myostatin, follistatin, interleukin 6 (IL-6), IL-6 receptors, insulin-like growth factor 1 (IGF-1), adiponectin, leptin, fibroblast growth factor 23 (FGF23), tumor necrosis factor SF12 (superfamily member 12) were studied in 87 patients.Results. According to the presence of the sarcopenic phenotype the patients differed in the levels of CRP (8.6 [1.3; 22.2] and 5.6 [1.2; 17.4] mg/l, respectively; p=0.041) and leptin (3.8 [2.4; 5.7] and 5.4 [3.8; 6.9] ng/ml, respectively; p=0.030). ALM correlated with the levels of CRP, follistatin and leptin. Linear multivariate regression analysis revealed the association between ALM index and follistatin (β=–0.35; p=0.007), IGF1 (β=–0.38; p=0.002), leptin (β=0.36; p=0.004) and FGF23 (β=0.33; p=0.008).Conclusion. The study showed that there is an association between the lean mass and the level of follistatin, IGF-1, leptin and FGF23 in patients with RA.
Institution: Association of Rheumatologists of Russia
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4405643669