Work

[1,2]‐Phospha‐Brook Rearrangement‐Initiated Palladium‐Catalyzed Cyclization Reaction of Isocyanides and o‐Bromobenzaldehydes: Access to 2H ‐Isoindole‐1‐carboxamides and 2H ‐Isoindole‐1‐carbonitriles

Year: 2024

Type: article

Abstract: Comprehensive Summary Herein, a [1,2]‐phospha‐Brook rearrangement‐initiated palladium‐catalyzed cyclization reaction for base‐controlled selective synthesis of 2H‐isoindole‐1‐carboxamide and 2H‐isoindole‐1‐carbonitrile derivatives has been described. This strategy features double isocyanide insertion, efficient bond combinations, simple operation and reaction conditions. Mechanistic studies show that the [1,2]‐phospha‐Brook rearrangement is the key step in this reaction. This protocol offers a novel and concise strategy for the synthesis of 2H‐isoindole derivatives.

Source: Chinese Journal of Chemistry

DOI: 10.1002/cjoc.202401015

Authors: Binbin Wang, Qiushan Gao, Huanfeng Jiang, Wanqing Wu

Institutions: State Key Laboratory of Luminescent Materials and Devices, South China University of Technology

Language: English

Topic: Synthesis of Indole Derivatives

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G2099619119, G3754285485, G7839754299