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Parasympathetic Dysfunction Prevails in GBA1 ‐Associated Parkinson's Disease

Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The role played by sympathetic and parasympathetic autonomic branches in patients with Parkinson's disease carrying variants in the GBA1 gene (GBA-PD) is still elusive. OBJECTIVES: To characterize cardiovascular autonomic function in GBA-PD and I-PD patients with early and mid-stage disease. METHODS: These assessments were performed: cardiovascular autonomic tests, analysis of heart rate and blood pressure variability, cardiac noradrenergic imaging. The frequency and severity of autonomic symptoms were comparatively assessed with the SCOPA-AUT questionnaire. RESULTS: Compared to the I-PD cohort, GBA-PD patients displayed an increased burden of autonomic symptoms. Autonomic tests revealed worse parasympathetic scores in GBA-PD while sympathetic indexes and the degree of cardiac sympathetic binding were comparable in the two groups. Heart rate variability indexes also revealed lower vagal modulation in the GBA-PD group. CONCLUSIONS: The cardiovascular autonomic profile in GBA PD is characterized by a prominent cardiovagal dysfunction compared to I-PD.
DOI: 10.1002/mdc3.14314
Authors: Tiziana De Santis, Antoniangela Cocco, Paolo Castiglioni, Maurizio Ferrarin, Rossana Mineri, Emanuela Morenghi, Micol Avenali, Alberto Albanese
Institutions: Humanitas University, IRCCS Humanitas Research Hospital, University of Milan, University of Insubria, Don Carlo Gnocchi Foundation, University of Pavia, Fondazione Istituto Neurologico Nazionale Casimiro Mondino, Università Cattolica del Sacro Cuore
Language: English
Subfield: Neurology
Field: Medicine
Open Access status: green
OpenAlex ID: W4405644269
FWCI: 0.229
Cites: 35
Cited by: 1
Related to: 10