Year: 2024
Type: article
Study design: Case Report
Abstract: ABSTRACT A 67‐year‐old male presented with plaques around the orbit and ecchymosis on the neck and back of hands for 2 years. Physical examination showed seborrheic‐keratosis‐like plaques around the orbit, ecchymosis on the neck and back of hands, as well as nail dystrophy. Serum λ light chain was positive. Histopathological examination demonstrated multiple keratinous cysts in the dermis and eosinophilic homogeneous material in the dermis, which was positive for Congo red with apple‐green birefringence on polarized light. Kidney biopsy showed deposition of acellular eosinophilic material in the arteriole wall. Congo red staining was positive. A bone marrow biopsy revealed multiple myeloma. The diagnosis of primary systemic amyloidosis with multiple myeloma was made.
Source: Journal of Cutaneous Pathology
DOI: 10.1111/cup.14763
Authors: Xiaoou Lu, Weiwei Fu, Demin Xie, Fengjuan Li, Jiali Zhang, Da Wang, Yu Sun, Hongquan Chen
Institution: Affiliated Hospital of Qingdao University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: Qingdao University
OpenAlex ID: W4405645310