Work

In vitro and in silico study of biological activity and toxicity of ambrosoartemisifolide and isoalantolactone sesquiterpene lactones obtained from the Ambrosia artemisiifolia L. and Telekia speciosa (Schreb.) Baumg. plant species

Year: 2024

Type: article

Abstract: In vitro study of antioxidant and antimicrobial properties of ambrosoartemisifolide and isoalantolactone sesquiterpene lactones obtained from ambrosia artemisiifolia (Ambrosia artemisiifolia L.) and beautiful telekia (Telekia speciosa (Schreb.) Baumg.) plants, common in Azerbaijan, and in silico study of biological activities and toxicity of these substances were carried out using computer modeling programs. Antioxidant properties of ambrosoartemisifolide and isoalantolactone sesquiterpene lactones were determined by spectrophotometry in the presence of DPPH (1,1-diphenyl-2-picrylhydrazyl) reagent. The antimicrobial activity of ambrosoartemisifolide and isoalantolactone against some bacteria was tested in vitro by the disk diffusion method and these compounds were found to have activity against Candida albicans, Staphylococcus aureus, Bacillus anthracoides, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae pathogenic bacteria. The bioactivity and toxicity of ambrosoartemisifolide and isoalantolactone were evaluated in silico based on computer modeling programs Pass Online, ProTox 3.0, Swiss ADME, and Molsoft L.L.C.

Source: INSTITUTE OF MOLECULAR BIOLOGY & BIOTECHNOLOGIES TRANSACTIONS

DOI: 10.62088/timbb/8.2.3

Authors: Ilhama Jahangirova, Kamala Badalova, Ilkin Nasirli, Cavanshir Isayev, Eldar Garayev

Institution: Azerbaijan Medical University

Language: English

Topic: Sesquiterpenes and Asteraceae Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W4405646340

FWCI:

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