Work

Systemic Scedosporium apiospermum Infection Affecting Multiple Sites After Near-Drowning: A Case Report

Year: 2024

Type: article

Abstract: : Scedosporium apiospermum ( S. apiospermum ) can cause fungal infections in near-drowning victims, and an increasing number of cases have been reported. However, cases of bone and joint infections caused by S. apiospermum are rare. In this case, a 35-year-old otherwise healthy Chinese female presented with aspiration pneumonia and knee arthritis after accidentally falling into sewage and near-drowning and underwent macrogenomic second-generation sequencing of arthrocentesis fluid, which showed S. apiospermum . However, new lesions involving the hip joint and spine continued to develop under voriconazole monotherapy. The patient was treated with voriconazole combined with amphotericin B cholesterol sulfate lipid complex for 30 consecutive days. The patient’s symptoms improved significantly. This case highlights the robust invasiveness of S. apiospermum and the extensive spread of infection, underscoring the importance of prompt diagnosis and treatment. A combined therapeutic approach may offer a safe and efficacious option for managing S. apiospermum infection. Keywords: near-drowning, Scedosporium apiospermum , voriconazole, amphotericin B cholesterol sulfate lipid complex, metagenomic next-generation sequencing

Source: Infection and Drug Resistance

DOI: 10.2147/idr.s483524

Authors: Aiping Zhang, Zijian Wang, Haoyu Sheng, Jianghua Yang

Institutions: Wannan Medical College, First Affiliated Hospital of Wannan Medical College

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836