Work

A randomized study on the impact of optimized modified ultrafiltration on the physiological parameters of infants and children undergoing a cardiopulmonary bypass

Year: 2024

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: BACKGROUND: The aim of this study is to assess the impact of optimized modified ultrafiltration (OMUF) on the physiological parameters of infants and children undergoing cardiopulmonary bypass (CPB). METHODS: In this randomized clinical trial, 30 pediatric patients were recruited and allocated into the experimental and control groups, each comprising of 15 patients. The experimental group underwent OMUF prior to the termination of CPB and extubation, while the control group received conventional modified ultrafiltration (MUF). RESULTS: In the experimental group, post-ultrafiltration levels of Na+, Ca++, hemoglobin (Hb), and hematocrit (HCT) exhibited a statistically significant increase compared to pre-ultrafiltration levels (p < 0.05), whereas no statistically significant differences were observed in the control group. CONCLUSION: The optimization of conventional MUF led to a significant enhancement in ultrafiltration efficacy, thereby exerting a beneficial impact on improving the physiological parameters of pediatric patients during CPB, surpassing conventional practices.

Source: Journal of Cardiothoracic Surgery

DOI: 10.1186/s13019-024-03183-y