Work

Managing the Expected, Diagnosing the Unexpected: A Rare Presentation of Undiagnosed Breast Carcinoma-A Case Report

Year: 2024

Type: article

Abstract: UrooncologyMicroscopic examination revealed an infiltrating epithelial tumor consisting of large, dyscohesive tumor cells arranged in groups varying in size and as single cells.The cells had a high N/C ratio, a small amount of eosinophilic cytoplasm, and a large hyperchromatic nucleus with moderate to high pleomorphism and moderate mitotic activity.Immunohistochemical (ICH) analysis showed strong positivity of malignant epithelial cells for GATA3, CK7, CK7/19, Estrogen receptor (100%), and gross cystic disease fluid protein-15 (GCDFP-15).They were nonreactive to E-cadherin, TTF-1, CDX2, CK20, and synaptophysin.HER2 receptor status was borderline.In situ hybridization did not detect gene amplification.Based on these findings, the specimen was a metastatic lobular BrC.

Source: Journal of Urological Surgery

DOI: 10.4274/jus.galenos.2024.2024-1-4

Authors: Stine Marie Dalsborg Madsen, Louise Andersen Lynggård, Christina Stilling, Pernille Skjold Kingo

Institutions: Regionshospitalet Viborg, Aarhus University Hospital

Language: English

Topic: Breast Lesions and Carcinomas

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4405653040