Work

Biologically defined neuronal synuclein disease as a tool to advance drug development

Year: 2024
Type: article
Abstract: In a recent Viewpoint article (JAMA Neurol. 2024;81:789‒90), Okubadejo et al. raised concerns regarding two recent proposals for biological definitions and staging systems for synucleinopathies (the Neuronal Synuclein Disease Integrated Staging System and SynNeurGe system). While acknowledging these concerns, we provide an alternative perspective—that such frameworks represent important steps forward by allowing biologically defined populations to be targeted with precision treatments that can be accurately evaluated using stage-specific outcomes.
Language: English
Subfield: Neurology
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,590
OpenAlex ID: W4405654532
FWCI: 1.072
Cites: 17
Cited by: 4
Related to: 10