Work

Newborn daughters get a fresh start through PI(3,5)P2-mediated vacuolar acidification

Year: 2024

Type: article

Abstract: Huda et al. (https://doi.org/10.1083/jcb.202406170) reveal a transient, cell cycle-dependent increase in PI(3,5)P2 levels at the lysosome-like vacuole of yeast daughter cells. The resulting lipid asymmetry alters vacuolar pH in both daughter and mother cells and will impact multiple downstream functions.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.202412054

Author: Patricia M. Kane

Institution: SUNY Upstate Medical University

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: Regulation and Cellular Functions of V-ATPases