Year: 2024
Type: article
Abstract: Aim Investigate associations between religion and spirituality (R&S) and DNA methylation of four HPA-axis genes (i.e. 14 CpG sites) among 992 adults from the Hispanic Community Health Study/Study of Latinos cohorts.Methods We assessed 1) the association between R&S measures and mean percent methylation overall and stratified by nativity status (US-born or immigrant) and 2) if interactions between R&S and methylation differed by nativity status.Results Among individuals with the FKBP5 CC genotype, increased spirituality scores were associated with significantly lower methylation levels among immigrants, compared to US-born participants. Organizational religiosity (e.g. service attendance) was associated with increased FKBP5 (CC genotype) methylation among immigrants.Conclusion R&S may influence HPA-axis functioning differently based on nativity status; a finding that could offer insight into mechanisms leading to health disparities.
Source: Epigenomics
Language: English
Subfield: Health
Field: Social Sciences
Domain: Social Sciences
Open Access status: green
Funders: Office of Dietary Supplements, John Templeton Foundation, University of Miami, Northwestern University, San Diego State University, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Minority Health and Health Disparities
Awards: G1004541261, G1042216835, G1081972346, G1301356587, G1312369436, Hispanic Community Health Study, G1455175283, G1587824183, G1666450717, G1917633662, G2135211244, G2135293100, G2466919156, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, G2501967490, G2528054427, G2575730562, G2644289446, G2970637568, G3062787641, Hispanic Community Health Study, G3543197244, G3677686024, G3838006641, G3952816605, G4121762840, Hispanic Community Health Study, G4552920371, G4860668542, Wandering Mazes Lost: Investigating Arguments over the Problem of Existence., G4989378220, G528357465, G5365244667, G543802643, G555858244, G5739677117, G5878028785, G5906656038, G6075306088, G6156511736, G6585687856, G6744188800, G7057037114, G7203655167, G7239480477, G7272721675, G7278742613, G7408420985, G7513901258, G7678550560, G8102260223, G820454163, G8386326007, HISPANIC COMMUNITY HEALTH STUDY-268065233, G8840902395, G8904081916, Adverse childhood experiences and alcohol misuse in Latino adolescents: testing biopsychosocial and cultural mechanisms.
OpenAlex ID: W4405657290