Work

HM13 is a predictive biomarker of metastasis and neutrophil infiltration in colorectal cancer.

Year: 2025

Type: article

Abstract: BACKGROUND: High levels of histocompatibility minor 13 (HM13) have been related to the progression of several cancers. Here, we investigated the function of HM13 in colorectal cancer (CRC). METHODS: verification of HM13 function. RESULTS: studies further confirmed that MPO overexpression partially abolished the inhibition of tumor growth by sh-HM13 in CRC. CONCLUSION: The results suggested that high HM13 expression in CRC could promote tumor growth and metastasis by reducing neutrophil infiltration and may serve as a useful target in the treatment of metastatic CRC.

Source: PubMed

DOI: 10.14670/hh-18-857

Authors: Yanbing Ren, Ying Mao, Xiao Yuan

Institutions: First Affiliated Hospital of Anhui Medical University, Anhui Medical University

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4405658331

FWCI:

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