Work

Stearic acid-capped mesoporous silica microparticles as novel needle-like-structured drug delivery carriers

Year: 2024

Type: article

Abstract: increased with increased stearic acid loading concentrations. The needle-structures phenomenon was corroborated by 3D confocal imaging. It utilised the autofluorescence properties of stearic acid to demonstrate its presence within the carrier, with fluorescence intensity increasing alongside the stearic acid concentration. Differential scanning calorimetry (DSC) indicated the crystalline nature of these needle structures, which was further confirmed by X-ray diffraction (XRD) analysis, validating the crystallisation of the stearic acid needles. Moreover, nitrogen porosimetry was employed to assess the pore volume and surface area, where the formulation containing 120 % stearic acid exhibited the lowest pore volume (0.59 cc). This value was smaller than unloaded SYLOID (2.1 cc), indicating near-complete filling of the carrier. This newly developed SYLOID-stearic acid carrier will now be used to enhance formulation development as a platform to enhance protein oral drug delivery.

Source: European Journal of Pharmaceutics and Biopharmaceutics

DOI: 10.1016/j.ejpb.2024.114619

Authors: Mohamad Anas Al Tahan, Ali Al-Khattawi, Craig Russell

Institution: Aston University

Language: English

Topic: Mesoporous Materials and Catalysis

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,270