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Protective Effect of Tribulus Terrestris on Hepato-biochemical Parameters of Albino Rat After Treatment With Drug Cyproterone Acetate

Year: 2023

Type: article

Abstract: The study investigates the hepatoprotective effects of Tribulus terrestris on albino rats subjected to cyproterone acetate, drug known for their hepatotoxicity. The experiment involved the administration of this drug to induce liver damage, followed by treatment with Tribulus terrestris extract. Hepato-biochemical parameters, including serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were monitored to assess liver function and damage. Results showed a significant elevation in ALT, AST and ALP levels in rats treated with cyproterone acetate, indicating liver damage. However, co-administration of Tribulus terrestris extract resulted in a marked reduction in these biochemical parameters, suggesting a protective effect on liver function. The study concludes that Tribulus terrestris exhibits substantial hepatoprotective and antioxidant effects, potentially mitigating the hepatotoxicity induced by cyproterone acetate. These findings suggest that Tribulus terrestris could be considered as a supplementary therapeutic agent to protect against drug-induced liver damage.

Source: Journal of Science Innovations and Nature of Earth

DOI: 10.59436/76z09z70

Authors: Ajay Pratap Singh, P.K. Singh, Harendra Nath Sharma

Institution: Dr. Bhimrao Ambedkar University

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4405664673

FWCI:

Cites: 3

Cited by:

Related to: 10