Evaluation of the effect of a natural monoterpenic phenol on the cytotoxicity of carfilzomib
Year: 2024
Type: article
Abstract: Aim: The aim of this study was to reveal whether carfilzomib, proteasome inhibitor, and carvacrol, a natural monoterpenic phenol, causes cytotoxic and apoptotic effects and oxidative stress on A-549 cells. Materials and Methods: Lactate dehydrogenase (LDH) activity test was used. Changes in caspase 3 and glutathione peroxidase enzyme activities in cells were determined. Results: It was determined that carfilzomib alone and together with carvacrol caused a raise in the activities of lactate dehydrogenase (LDH), glutathione peroxidase and apoptotic enzyme, caspase-3 activity, compared to the control. Conclusion: Our study showing that carfilzomib alone and together with carvacrol gave different responses may be guiding in determining new strategies to be applied in lung cancer treatment.
Author: Ayşe Erdoğan
Institution: Alanya Alaaddin Keykubat Üniversitesi
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4405665829