Proliferative Myositis of the Breast in a Patient with Contralateral Phyllodes Tumor: A Unique Pseudomalignant Lesion
Year: 2024
Type: article
Study design: Case Report
Abstract: AIM: We report a case of proliferative myositis (PM) of the breast, which is the second reported in the English literature. CASE PRESENTATION: A 49-year-old woman underwent surgery due to a fibroadenoma in the right and phyllodes tumor in the left breast. One month after these surgeries, a right breast mass rapidly grew at the surgical site, and biopsy did not provide a diagnosis. The lesion's rapid growth and high cellularity led to a suspicion of malignancy, and the mass was surgically removed. The immunohistochemical markers used were estrogen receptor (ER), S100, smooth muscle actin (SMA), desmin, pan-cytokeratin, Myoblast Determination Protein 1 (MyoD1), myogenin, caldesmon, calretinin, CD34, Anaplastic Lymphoma Kinase (ALK), P53, P63, and Ki67. A low Ki67 index and mitosis, lack of staining with rhabdomyosarcoma markers, and a typical checkerboard pattern ruled out malignancy. The diagnosis was PM. CONCLUSIONS: This case emphasizes the importance of recognizing pseudomalignant breast masses to avoid catastrophic overtreatment.
Source: Annali Italiani di Chirurgia
DOI: 10.62713/aic.3915
Author: Zuhal Silav
Institution: Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4405669676