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Voltamper-metrical definition of potential protective virus medicine sodium salt of 3-nitro-4-hydroxy-7-metiltio-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazinide monohydrate

Year: 2024

Type: article

Abstract: The sodium salt of 3-nitro-4-hydroxy-7-methylthio-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazinide monohydrate (compound (1)) is one of the promising compounds that showed potential antiviral activity against Coxsackie B3 virus. It was established by cyclic voltammetry that the electrochemical activity of compound 1 on a glass-carbon electrode in Britton-Robbinson buffer solution (BBR) is due to the electroreduction of the nitro group. A method for the determination of compound 1 by direct cathodic square-wave voltammetry was developed. The linearity area of the graduation plot using the developed method in BBR solution (pH 2.0 ± ٠.١) is 10-300 mg/L (R2 = 0.999) with detection and determination limits of 1.27 and 4.11 mg/L, respectively.

Source: Journal of Analytical Chemistry

DOI: 10.31857/s0044450224060103

Authors: P. N. Mozharovskaya, A. V. Ivoylova, N. A. Malakhova, R. A. Drokin, I. A. Balin, A. N. Kozitsina, A. V. Ivanova, V. L. Rusinov

Institutions: Ural Federal University, Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Language: English

Topic: Electrochemical Analysis and Applications

Subfield: Electrochemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4405681146

FWCI:

Cites: 17

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Related to: 10