Work

Adenoid basal cell carcinoma: An underrecognized cervical malignancy

Year: 2024

Type: article

Abstract: • Cervical ABC is a rare malignancy that is at risk of misclassification. • Cervical ABCs are associated with good prognosis but are frequently diagnosed in conjunction with more aggressive pathology. • Treatment of cervical ABCs should be focused on coexisting pathology per standard treatment recommendations. Adenoid basal cell carcinoma is a rare cervical malignancy which is indolent in nature but resembles more commonly occurring aggressive malignancies. Here we describe three cases of cervical adenoid basal cell carcinoma. All patients had a history of cervical dysplasia with high-risk HPV. The first and second patient were treated with hysterectomy, and the third patient opted for surveillance after cold knife conization. All patients have no evidence of disease to date. Cervical adenoid basal cell carcinoma is a rare malignancy that requires careful diagnostic attention due to its histologic similarities to more aggressive malignancies and the risk of misclassification. Advances in diagnostic criteria including immunohistochemistry (IHC) classification are key to distinguishing this unique pathological entity. Definitive treatment depends on accurate diagnosis. Optimal treatment involves surgical management with hysterectomy and lymph node assessment. Excisional biopsy with thorough pathologic evaluation for invasive carcinoma can be considered in patients who desire future fertility.

Source: Gynecologic Oncology Reports

DOI: 10.1016/j.gore.2024.101667