Work

LH level on trigger day, number of follicles ≥16 mm but <18 mm, and number of retrieved oocytes are independent risk factors for polyspermy in gonadotropin-releasing hormone antagonist protocol

Year: 2024

Type: article

Abstract: Introduction The polyspermy rate is a quality control indicator in the embryology laboratory, and factors affecting polyspermy are of great interest. The gonadotropin-releasing hormone (GnRH) antagonist protocol is currently the mainstream protocol in most reproductive centers. This study explored the factors influencing polyspermy in in vitro fertilization (IVF) using the GnRH antagonist protocol and considered corresponding improvement measures. Methods This retrospective case-control study analyzed 354 patients who underwent conventional IVF with a GnRH antagonist protocol at Zigong Maternal and Child Health Hospital from November 2019 to September 2023. Patients were divided into two groups based on the occurrence of polyspermy, and baseline characteristics and clinical data were compared between the groups. Variables with P<0.05 in univariate logistic regression were included in the multivariate logistic regression model. Cutoff values for variables with P<0.05 were calculated. Results Multivariate logistic regression corrected for confounding factors identified that luteinizing hormone (LH) level on trigger day, the number of follicles ≥16 mm but <18 mm, and the number of retrieved oocytes were significantly associated with polyspermy (OR=1.305, P=0.005; OR=1.235, P=0.002; OR=1.101, P<0.001, respectively). The cutoff values were 1.95 IU/L, 4.5 follicles, and 16.5 oocytes, respectively. Conclusion In the GnRH antagonist cycle, LH level on trigger day, the number of follicles ≥16 mm but <18 mm, and the number of retrieved oocytes are independent risk factors for polyspermy. When LH level on trigger day exceeds 1.95 IU/L, the number of follicles ≥16 mm but <18 mm exceeds 4, and the number of oocytes retrieved exceeds 16, the risk of polyspermy increases significantly.

Source: Frontiers in Endocrinology

DOI: 10.3389/fendo.2024.1521734

Authors: Qiongyu Wu, Lina He

Language: English

Topic: Reproductive Biology and Fertility

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295

Funder: Natural Science Foundation of Sichuan Province