Characterization of Arabidopsis thaliana FRATAXIN HOMOLOG in heme catabolism
Year: 2024
Type: article
Abstract: Frataxin plays vital roles in various iron related processes. Arabidopsis thaliana FRATAXIN HOMOLOG (AtFH) is the first identified plant frataxin and has been found to regulate the last step of heme biosynthesis. Here, we report the involvement of AtFH in heme catabolism by regulating the activity of heme oxygenase. AtFH forms a homodimer, and its crystal structure shows the dimeric interactions. A structural comparison with known frataxin structures suggests the iron binding sites, and the site for heme oxygenase activity is possibly located in a region containing Glu78. The results indicate a previously uncharacterized role of plant frataxin in heme catabolism.
Source: Biochimie
Authors: Jing Zhang, Yingying Zhou, Qianyi Duan, Xinhe Xu, Xiao Wang, Jia Wang, Lin Liu
Institution: Anhui University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,880
OpenAlex ID: W4405695592