Work

Dual-stimuli-responsive nanoparticles for the co-delivery of small molecules to promote neural differentiation of human iPSCs

Year: 2024

Type: article

Abstract: formation of neural rosettes but also modulated the expression levels of key markers. In particular, it downregulated OCT4, a marker of pluripotency, while upregulating PAX6, a critical marker for the neuroectoderm. These findings suggest that this controlled small molecule release system holds significant potential for therapeutic applications in neural development and neurodegenerative diseases.

Source: Nanoscale

DOI: 10.1039/d4nr04413d

Authors: Jeong Hyun You, Na Yeon Kim, Yoon Young Choi, Hyung Woo Choi, Bong Geun Chung

Institution: Sogang University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze