Work

General access to furan-substituted gem -difluoroalkenes enabled by PFTB-promoted cross-coupling of ene-yne-ketones and difluorocarbene

Year: 2024

Type: article

Abstract: An efficient method for the tandem cyclization cross-coupling of conjugated ene-yne-ketones with difluorocarbene via PFTB promotion is described, providing facile access to diverse furan-substituted difluoroalkenes with potential antitumor potency.

Source: Chemical Science

DOI: 10.1039/d4sc08247h

Authors: Na Li, Chenghui Li, Qianying Zhou, Xin Zhang, Zhouming Deng, Zhong-Xing Jiang, Zhigang Yang

Institutions: Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan Institute of Physics and Mathematics, Wuhan National Laboratory for Optoelectronics, Innovation Academy for Precision Measurement Science and Technology, CAS

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: diamond

Funders: National Natural Science Foundation of China, Natural Science Foundation of Hubei Province, Wuhan University, National Key Research and Development Program of China

Awards: G401700272, G5992632799, G8471431863

OpenAlex ID: W4405696561

FWCI: 0.729

Cites: 82

Cited by: 5

Related to: 10