Work

Identification of CD8+ Immunogenic Peptides for Vaccine Design against Nipah Virus in Humans

Year: 2024

Type: article

Abstract: Background: Nipah virus is a pathogenic virus of ruinous zoonotic potential with inflated rate of mortality in humans. Methods: Considering the emerging threat of this pandemic virus, the present investigation amid to design vaccine by using the bioinformatics tools such as host and virus codon usage analysis, CD8+ peptide prediction, immunogenicity/allergenicity/toxicity, MHC-I allele binding prediction and subsequent population coverage and MHC-I-peptide docking analysis. Results: In this study (conducted in 2022 at School of Biotechnology, Katra, India), a set of 11 peptides of the structural proteins of Nipah Virus were predicted and recognized by the set of MHC-I alleles that are expressed in 92% of the global human population. Conclusion: The strong interactions between these peptides and the MHC-I protein suggest them as strong peptide candidates for the development of vaccine against Nipah Virus.

Source: Iranian Journal of Public Health

DOI: 10.18502/ijph.v53i12.17331

Authors: Pankaj Suden, Inderpal Singh, Chitrakshi Chopra, Malvika Mehta, Ratna Chandra, Indu Bhushan

Institution: Shri Mata Vaishno Devi University

Language: English

Topic: vaccines and immunoinformatics approaches

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $300