Work

Copper and DMAP Relay‐Catalyzed Three‐Component coupling of Terminal Alkynes, Anthranils and Alcohols for the Modular Synthesis of 2‐alkoxy Quinolines

Year: 2024

Type: article

Abstract: A copper and DMAP relay‐catalyzed strategy has been achieved for the modular synthesis of 2‐alkoxy quinolines from a three‐component coupling of terminal alkynes, anthranils, and alcohols. In this protocol, a novel quinoline pyridine salt is formed and serves as a key intermediate in the formation of 2‐alkoxy quinolines. The reaction has a broad substrate scope of each reaction partners, affording diversified 2‐alkoxy quinoline products in generally good yields.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.202401293

Authors: Haixia Li, Yang Gao, Xiongwei Zhong, Yanping Huo, Xianwei Li, Qian Chen

Institutions: Guangdong University of Technology, South China University of Technology

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Guangdong University of Technology

Award: G2661633844