A Multifunctional Ru‐Re Complex for Photodynamic Therapy and CO‐Mediated Therapeutics in Alzheimer's Disease
Year: 2024
Type: article
Abstract: The development of multifunctional therapeutic agents is crucial for addressing complex diseases such as Alzheimer's disease. Herein, we report a ruthenium‐rhenium (Ru−Re) complex that combines photodynamic therapy (PDT) and carbon monoxide (CO) generation capabilities. The Ru−Re complex shows promising photophysical property and significant therapeutic potential. Our studies reveal the complex's ability to generate singlet oxygen (1O2), CO, inhibit tau aggregation, and enhance mitochondrial respiration. These multifunctional properties position the Ru−Re complex as a versatile tool for therapeutic applications in Alzheimer's disease.
Source: Chemistry - A European Journal
Authors: Chun Hau Gan, Hsin‐Jou Chen, Ricky Yu‐Syun Fan, Siao‐Cian Pan, Kien Voon Kong
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: A Platform for Multiplexed VI Ruses Protein Sensing via Surface Enhanced Raman Scattering( II ), G2128239306, G3702019605, G4946452565, G5221813748, Development of a Real-Time Activity Detection Strategy for Glycoconjugates on the Cell Surface( I ), G6145644868, Effect of Local Environments on Catalytic Pathways: from Ensemble-Based to Single-Molecule Measurements( I ), G6919510699, G6925751520, Advancing Catalytic Therapeutics: Synthesis and Evaluation of Transition Metal Compounds to Nanoparticle Constructs for Carbon Monoxide Generation in Living Cells
OpenAlex ID: W4405706473