Work

The mitochondrial lactate oxidation complex: endpoint for carbohydrate carbon disposal

Year: 2024

Type: article

Abstract: We expand on knowledge of the architectural design of the mitochondrial lactate oxidation complex (mLOC); key members are: mitochondrial lactate dehydrogenase (mLDH), monocarboxylate transporter 1 (mMCT1), cytochrome oxidase (COx), basigin scaffolding protein (CD147), and the mitochondrial pyruvate carrier (mPC). The mLOC is key in creating the lower end of the concentration gradient for disposal of lactate and pyruvate.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00306.2024

Authors: Robert G. Leija, Jose A. Arevalo, Dianna Xing, José Pablo Vázquez-Medina, George A. Brooks

Institution: University of California, Berkeley

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: University of California Berkeley, National Institutes of Health, National Institute on Aging, National Institute of General Medical Sciences

Awards: G7562862327, G8038110770, G9000003951, G9000129973, The Biology of Peroxiredoxin 6