Work

An Efficient Synthetic Methodology for the Preparation of Glycosyl β‐diketones

Year: 2024

Type: article

Abstract: In this study, we present a synthetic methodology for preparing glycosyl β‐diketones from the corresponding allyl ethers. The process involves three steps: nitrile oxide cycloadditions, reduction of the glycosyl isoxazolines, and oxidation of β‐hydroxyketones. This route is suitable for acid‐ and base‐sensitive protecting groups, and the reactions were conducted with retention of the anomeric configuration. The resulting glycosyl β‐diketones were then utilized in the synthesis of the corresponding pyrazoles.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202401366

Authors: Ivan A. Barri, Macarena S. Le Pors, Pedro A. Colinas

Institution: Universidad Nacional de La Plata

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de La Plata

Awards: G134289979, G2201927893, G5013247056