CORM‐Mediated Pd‐Catalyzed Coupling Reactions: Ketone Synthesis and CO‐Releasing Mechanisms
Year: 2024
Type: article
Abstract: Palladium‐catalyzed carbonylative C─C coupling reactions provide an efficient route to synthesize natural products and pharmaceuticals through three‐component condensation processes. However, the use of gaseous carbon monoxide (CO) – a colorless, odorless, and toxic gas – has hindered its broad adoption as a C1 source. Addressing this, the development of versatile CO‐releasing molecules (CORMs) and user‐friendly, nongaseous palladium‐catalyzed carbonylation techniques have emerged as a crucial research area. This review outlines recent advancements in the application of CORMs to palladium‐catalyzed carbonylative C─C coupling reactions, with a focus on CO generation mechanisms and carbonyl utilization efficiency. CORMs are classified into three categories: single carbon monoxide releasing molecules (s‐CORMs), multiple carbon monoxide releasing molecules (m‐CORMs), and binary metal carbonyl compounds (BMCCs). By offering a comprehensive overview of the current research landscape and providing practical guidelines for CORM selection, this review aims to assist researchers in developing effective carbonylative strategies.
Source: ChemCatChem
Authors: Meng Guo, Hongyu Yang, Jiawei Wang, Yajun Jian, Weiqiang Zhang, Ziwei Gao
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Award: G23277181
OpenAlex ID: W4405707979